Dr. Levy on MTHFR Gene Mutation “Any experts on the MTHFR gene polymorphisms out there? I have trouble thinking of it as a mutation. How can 40% or more of the population have this "mutation" and it is only a problem if you are poisoned or eating a garbage diet. To me it no different to saying that red hair is a mutation. I have trouble considering polymorphisms that are so prevalent, a disease or a mutation. It seems like a "state" to me, and while I appreciate the significance, I don't appreciate the terminology. Those with it, are not sick, unless something goes into the body that should not be there, or they do not get enough of the right type of folate. “ -Suzanne Humphries “Mthfr impairs metabolic pathways causing oxidative stress. Vitamin c neutralizes oxidative stress. In a sense vitamin c resolves mthfr.
I believe a riboflavin deficiency is a mthfr issue. Riboflavin is the precursor to FAD the coenzyme required for the activity of the folate metabolizing enzyme, also known as mthfr.
I also believe vitamin c alone can cure mthfr. The issue is low riboflavin and enzyme deficiency. Vitamin c is the precursor to these enzymes. Not only that but it enhances the absorption of all vitamins and minerals.”
"I am no expert on MTHFR or the impact of methylation in the body, except to say that it is very important. However, I have asserted for a long time now that all disease, and all organ or tissue malfunction, has at its basis and final common denominator increased oxidative stress. Basically, any genetic mutation or insufficiency ultimately impairs one or more metabolic pathways such that increased oxidative stress occurs at the molecular level in the affected cells or tissues. Depending on what is missing, vitamin C can completely compensate, or only partially compensate for this increased oxidative stress, depending on a number of different factors. Generally, a genetic deficiency is going to affect metabolic pathway efficiency, and loss of a functional enzyme or biomolecule can minimally to greatly decrease the efficiency of given metabolic pathways. Hope this helps. Best regards," Dr. Levy